+353 (1) 685 6929 Nickel Sensitivity and Allergy DNA Test
Nickel is a widely used metal found in everything from jewellery and coins to smartphones and even food. While harmless to most, some individuals experience allergic reactions when exposed to it. These reactions can range from skin irritation to more systemic symptoms such as digestive discomfort and chronic fatigue.
The Nickel Sensitivity DNA Test analyses genetic variants linked to how your body reacts to nickel. By identifying your genetic predisposition, this test helps you understand whether you’re more likely to experience allergic responses and gives you the information you need to take control of your wellbeing.
What You’ll Learn from The Nickel Sensitivity DNA Test
This test explores two key genes involved in nickel sensitivity—FLG (Filaggrin) and TNF-α (Tumour Necrosis Factor Alpha). These genes are crucial in maintaining your skin barrier and regulating your immune system’s inflammatory responses. Understanding your results can empower you to make practical changes that reduce your risk of nickel-triggered reactions.
Your Genetic Predisposition: Discover whether you carry genetic variants that may increase your sensitivity to nickel.
Risk of Symptoms: Learn if you are more susceptible to conditions like Allergic Contact Dermatitis or Systemic Nickel Allergy Syndrome (SNAS)—a condition that can trigger digestive issues, fatigue, and more.
Personalised Health Advice: Gain practical, DNA-based guidance on how to avoid nickel exposure, adjust
Want to see what your results will look like?
The Science Behind the Nickel Sensitivity Test
Nickel sensitivity is influenced by the way your body interacts with allergens. This DNA test focuses on two genetic markers that have been scientifically linked to allergic reactions and inflammatory responses.
FLG Gene (Filaggrin)
The FLG gene plays a critical role in creating and maintaining your skin’s protective barrier. Mutations in this gene can:
Allow allergens like nickel to pass through the skin more easily
Increase the likelihood of developing allergic contact dermatitis (itching, redness, blistering)
Lead to chronic skin dryness, delayed healing, and increased skin sensitivity
TNF-α Gene (Tumour Necrosis Factor Alpha)
This gene encodes a pro-inflammatory cytokine that regulates immune responses. Unfavourable variants in this gene may:
Heighten inflammatory reactions to nickel exposure
Increase the risk of systemic symptoms including digestive upset, headaches, and fatigue
Worsen pre-existing inflammatory skin conditions such as eczema
By identifying if you carry unfavourable variants in these genes, the test helps explain why you may react to nickel and how to manage your sensitivity proactively.
Nickel Sensitivity DNA Test: a Simple Process
Getting tested couldn’t be easier. There’s no need for a blood sample or clinic visit. We’ll send you a home sample collection kit that includes sterile buccal swabs and clear instructions.
All you need to do is rub the swab inside your cheek, return the sample using the prepaid envelope, and we’ll do the rest.
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Report Features & Results Format of the Nickel Sensitivity DNA Test
Your results come in a comprehensive and easy-to-understand report that includes:
Clear Explanations – Learn what your genetic results mean and how they affect your sensitivity to nickel
Summary Table – Quickly see how your genes performed and which areas may need attention
Colour-Coded Results – Understand your risk level at a glance:
Scientific References – For those who want to explore the research behind the results, the report includes a full bibliography
Understanding Nickel Sensitivity
Nickel intolerance can manifest in different ways. Here are the most common symptoms associated with sensitivity:
Allergic Contact Dermatitis – Occurs when the skin touches nickel-containing objects like jewellery, watches, coins, or mobile phones. Symptoms include itching, rashes, redness, and even blistering.
Systemic Nickel Allergy Syndrome (SNAS) – A more severe reaction triggered by dietary nickel. Common symptoms include bloating, diarrhoea, nausea, headaches, fatigue, and general malaise.
Aggravated Chronic Conditions – Nickel exposure can worsen pre-existing conditions such as eczema, asthma, or gut inflammation.
Genetic predisposition doesn’t guarantee that you’ll develop symptoms—but knowing your risk helps you take the right precautions early.
Managing Nickel Sensitivity: Practical Advice
If your DNA test shows unfavourable variants in the FLG or TNF-α genes, you can take practical steps to reduce symptoms. Limit exposure to nickel by choosing nickel-free jewellery, using hypoallergenic personal care products, and following a low-nickel diet—avoiding foods like chocolate, legumes, and canned goods, while focusing on fresh, unprocessed options.
Support your skin with gentle, fragrance-free products and daily moisturisers containing ceramides. Adopt an anti-inflammatory lifestyle by eating foods rich in omega-3s and antioxidants, reducing processed foods, and managing stress through relaxation techniques. If symptoms persist, consult a healthcare professional and consider combining your genetic results with allergy testing for personalised care.
Take Control of Your Health Today
This test is an important first step in understanding how your body responds to one of the most common environmental allergens. Whether you’ve experienced symptoms in the past or simply want to be proactive, the Nickel Sensitivity DNA Test offers valuable insights you can act on..
Your genetic results can guide your daily decisions—from what to eat to what skincare products to use—helping you avoid flare-ups, manage inflammation, and live more comfortably.
Disclaimer: Test results are for informational and educational purposes only. They are not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare provider before making changes to your healthcare routine.
